Effect of poly-glutamate on uptake efficiency and cytotoxicity of cell penetrating peptides

PROJECT TITLE :

Effect of poly-glutamate on uptake efficiency and cytotoxicity of cell penetrating peptides

ABSTRACT:

Cell penetrating peptides (CPPs) were developed as vehicles for efficient delivery of varied molecules. An ideal CPP-peptide should not display any toxicity against cancer cells plus healthy cells and efficiently enter into the cell. As a result of of the cationic nature and the intrinsic vector capabilities, these peptides will cause cytotoxicity. One in every of the doable reasons for toxicity of CPPs is direct translocation and consequently, pore formation on the plasma membrane. In this study it absolutely was demonstrated that interaction of poly-glutamate with CPP significantly reduced their cytotoxicity in A549 cell. This strategy may be useful for economical drug delivery mediated by CPP.

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